Read e-book online Animal Models in Toxicology 2nd Edition (Drug and Chemical PDF

By C. Gad Shayne

ISBN-10: 0824754077

ISBN-13: 9780824754075

Reflecting greater than a decade’s worthy of adjustments, Animal versions in Toxicology, moment variation is a realistic advisor to the typical statistical difficulties encountered in toxicology and the methodologies which are to be had to resolve them. The ebook provides a historic evaluate of using animal types and an outline of vast issues of metabolism and relevance utilized in toxicology. person chapters masking the 8 significant species utilized in toxicology and experimental biology shape the middle of the publication. With contributions from specialists in toxicology, toxicological pathology, and species-specific metabolism, every one of those chapters supply a good introductory “course” in addition to tips to the literature for extra distinctive realizing. The publication is going directly to make the case for various species no longer established for safeguard review experiences yet which can offer beneficial substitute versions for a few particular endpoints. The bankruptcy authors talk about designated concerns concerning theevaluation and interpretation of the scientific pathology of the 8 significant version species in addition to tips on how to choose a version species and the way to extrapolate the implications to people. They element power pitfalls and occasions that reason both human or version to be considerably extra delicate than the opposite or completely inappropriate to one another. The publication concludes with an outline of the more and more complicated legislation and laws that govern how laboratory animals are acquired, maintained, and applied, and an appendix that offers a brief consultant to advertisement resources of laboratory animals.

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Read Online or Download Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology) PDF

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Additional info for Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology)

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Calabrese, E. (1988). Comparative biology of test species. Environ. Health Perspec. 77, 55–62. Caldwell, J. (1981). The current status of attempts to predict species differences in drug metabolism. Drug Metab. Revs. 12, 221–237. 16 ANIMAL MODELS IN TOXICOLOGY Caldwell, J. (1982). Conjugation reactions in foreign-compound metabolism: Definition, consequences, and species variations. Drug Metab. Revs. 13, 745–777. Cayen, M. (1987). Retrospective evaluation of appropriate animal models based on metabolism studies in man.

1947). Detoxification mechanisms: The metabolism of drugs and allied organic compounds. New York: Wiley. Williams, R. T. (1972). Species variation in drug biotransformations. In Fundamentals of drug metabolism and drug disposition, eds. B. LaDu, H. Mandel, and E. Way, 187–205. Baltimore: Williams & Wilkins. Williams, R. T. (1974). Inter-species variations in the metabolism of xenobiotics. Biochem. Soc. Transat. 2, 359–377. Wong, K. (1976). Species differences in the conjugation of 4-hydroxy-3-methoxypheylethanol.

1975. seen in more conventional strains, but the incidences are higher and the latency periods shorter. There is a wide spectrum of susceptibility to spontaneous lung tumors in various strains of mice, and evidence suggests that there is a high correlation between spontaneous incidence and chemical inducibility in those various strains (Shimkin and Stoner 1975). The inbred strain A mouse appears to be the most susceptible to lung tumors, and forms the basis of a lung tumor bioassay, with tumors inducible within 8 weeks or less of treatment.

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Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology) by C. Gad Shayne

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