Advances in Pharmacology - download pdf or read online

By Silvio Garattini and Parkhurst A. Shore (Eds.)

ISBN-10: 0120329026

ISBN-13: 9780120329021

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At the lower dose none of the compounds had any influence on the white blood cell counts. This example clearly demonstrates that decrease of blood leucocyte counts may occur if animals are overdosed with drugs. But these changes as well as other organ damages are easier to produce with certain drugs, Thus, there is a gradual transition from nonspecific organ damage to drug-induced changes with high order of specificity. B. DRUG-INDUCED CHANGESWITH Low ORDER OF SPECIFICITY 1. Impaired Nutrition Reduced food intake is one of the most common complications of chronic toxicity experiments.

Inhibition of spermatogenesis also often occurs in dogs. The question whether or not a chronic disease may influence toxicity of a drug is difficult to answer, since in spontaneously dying animals very peculiar organ changes are often observed which are never found in healthy animals and may have resulted from either a disease or the drug. It is our impression, however, that chronic diseases rarely accentuate drug toxicity in experimental animals. ). 25% isoniazid for 2 more weeks to the end of the experiment.

B. SEX Minor differences in response to drugs between male and female animals are quite frequently seen in toxicity experiments. , 1959), the more pronounced fatty change of the liver in 38 GERHARD ZBINDEN male rats on a diet containing 5% chlortetracycline (Dessau and Sullivan, 1961)) the more pronounced depressant effect on weight gain of Lthyroxin, also in male rats (Grossie and Turner, 1961), and the higher toxicity of hypoglycemic agents in female rats and rats pretreated with diethylstilbestrol (McColl and Sacra, 1962).

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Advances in Pharmacology by Silvio Garattini and Parkhurst A. Shore (Eds.)

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