By Silvio Garattini and Parkhurst A. Shore (Eds.)
Read or Download Advances in Pharmacology PDF
Similar toxicology books
Phone tradition has stepped forward to the purpose the place cells should be grown into tissue-like buildings in vitro, yet those tissues frequently endure little resemblance to an analogous tissue in a residing organism. This booklet describes tools of culturing epithelial cells so that it will mimic effectively their behaviour in vivo, and the ensuing version platforms can be utilized in quite a lot of examine components: pharmaceutics, pharmacology, toxicology, and mobile biology.
Deals accomplished assurance of the indoor environment-integrating future health and construction technology and proposing quite a few viewpoints from different disciplines, together with allergic reaction, toxicology, oncology, environmental technological know-how, development engineering, and legislations. Examines serious concerns that impact air caliber from a resource viewpoint, akin to biologic brokers, insecticides, tobacco smoke, solvents, combustion items, risky natural compounds, indoor allergens, and radon.
The security of human well-being and meals and fiber assets opposed to the ravages of pests of many varieties is a continual fight through everybody on the planet. using chemical insecticides as an relief during this fight is now additionally worldwide. those chemical substances are intentionally extra to the surroundings for the aim of killing or injuring a few type of lifestyles.
- Handbook of Toxicologic Pathology
- Endocrine disruptors : effects on male and female reproductive systems
- Gulf War Syndrome: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
- Toxicology and Occupational Medicine. Proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine, Key Biscayne (Miami), Florida, October 22–25, 1978
- Mechanisms of Cadmium Toxicity to Various Trophic Saltwater Organisms
Additional info for Advances in Pharmacology
At the lower dose none of the compounds had any influence on the white blood cell counts. This example clearly demonstrates that decrease of blood leucocyte counts may occur if animals are overdosed with drugs. But these changes as well as other organ damages are easier to produce with certain drugs, Thus, there is a gradual transition from nonspecific organ damage to drug-induced changes with high order of specificity. B. DRUG-INDUCED CHANGESWITH Low ORDER OF SPECIFICITY 1. Impaired Nutrition Reduced food intake is one of the most common complications of chronic toxicity experiments.
Inhibition of spermatogenesis also often occurs in dogs. The question whether or not a chronic disease may influence toxicity of a drug is difficult to answer, since in spontaneously dying animals very peculiar organ changes are often observed which are never found in healthy animals and may have resulted from either a disease or the drug. It is our impression, however, that chronic diseases rarely accentuate drug toxicity in experimental animals. ). 25% isoniazid for 2 more weeks to the end of the experiment.
B. SEX Minor differences in response to drugs between male and female animals are quite frequently seen in toxicity experiments. , 1959), the more pronounced fatty change of the liver in 38 GERHARD ZBINDEN male rats on a diet containing 5% chlortetracycline (Dessau and Sullivan, 1961)) the more pronounced depressant effect on weight gain of Lthyroxin, also in male rats (Grossie and Turner, 1961), and the higher toxicity of hypoglycemic agents in female rats and rats pretreated with diethylstilbestrol (McColl and Sacra, 1962).
Advances in Pharmacology by Silvio Garattini and Parkhurst A. Shore (Eds.)