By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This e-book is the 7th quantity within the sequence "Acute publicity guide degrees for chosen Airborne Chemicals", and comprises AEGLs for acetone cyanohydrin, carbon disulfide, monochloroacetic acid, and phenol. on the request of the dep. of protection, the nationwide examine Council has reviewed the proper medical literature compiled via knowledgeable panel and tested Acute publicity guide degrees (AEGLs) for 12 new chemical substances. AEGLs symbolize publicity degrees less than which opposed wellbeing and fitness results usually are not prone to take place and are worthwhile in responding to emergencies similar to unintended or intentional chemical releases locally, the office, transportation, the army, and for the remediation of infected websites. 3 AEGLs are authorized for every chemical, representing publicity degrees that lead to: remarkable yet reversible soreness; long-lasting wellbeing and fitness results; and, life-threatening health and wellbeing affects.
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7
No other signs of toxicity were reported. Izmerov et al. 8 ppm) for 2 h in rats (no details reported). 5 min. When the free HCN contained in the acetone cyanohydrin was removed by precipitation with silver nitrate before exposure, the authors found that collapse occurred after an average time of 4 min and 50 % mortality after 10 min (the exact number of animals not stated). Monsanto (1986a) exposed groups of 10 female and 10 male SpragueDawley rats to acetone cyanohydrin at 0, 10, 30, or 60 ppm for 6 h/d, 5 d/wk for 20 exposure days (28 days in total).
This fact is reflected in comparatively high values for the TLV (Threshold Limit Value) (ACGIH 1997) of 500 ppm for 8 h with a 750-ppm STEL (short-term exposure limit), the IDLH (immediately dangerous to life and health concentrations) of 2,500 ppm (NIOSH 1996), and the EEGL (emergency exposure guidance levels) of 1,000 ppm for 24 h and 8,500 ppm for 1 h (NRC 1984). Acetone and its metabolic products (Casazza et al. 1984; Kosugi et al. 1986; Gentry et al. 2003) contribute only insignificantly to the toxicity of acetone cyanohydrin.
This 28 Acute Exposure Guideline Levels reaction is a result of the physical chemistry of acetone cyanohydrin (Stewart and Fontana 1940), and it is not known to be enzyme-catalyzed in animals or humans (Kaplita and Smith 1986; DECOS 1995). Acetone cyanohydrin is miscible with water and is taken up by the moist respiratory passages. The pulmonary retention of acetone cyanohydrin has not been reported, but it is probably in the range for HCN (about 58%; ATSDR 1997), acrylonitrile (about 50%; ATSDR 1990), and acetone (70-80%; ATSDR 1994).
Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7 by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels