By David O. Cooney
Highlighting activated charcoal's nice effectiveness in treating drug overdoses and poisonings in either people and animals, this accomplished, single-source reference brings jointly important info from each major learn at the use of activated charcoal for clinical purposes-describing all on hand charcoal items and their features.
Details activated charcoal's skill to lessen the systemic absorption of an enormous array of gear, chemical substances, and biochemical substances-including analgesics, antipyretics, sedatives, alkaloids, snake venoms, and bacterial and fungal pollutants.
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Extra info for Activated Charcoal in Medical Applications, Second Edition
3. Particle sizes: In the order listed, from left to right, the percentages of particles less than 150 urn (100 mesh) are 97,97,97,97,99,90, and 98. 4. Phenazone (antipyrine) adsorption values are given for the Norit B Supra and Norit A Supra as 41 and 50%, respectively (phenazone adsorption criteria appear in the pharmacopeias for some countries). Chapter 3 22 Norit SG Extra, Norit SG, and Norit 211, respectively, and (3) the values given for mois ture content, acid-solubles, and water-solubles are generally maximum expected values.
For example, water, being a very polar solvent, has a great affinity (and therefore solubility) for polar solutes. This means that water will tend to hold onto a polar solute and prevent its being bound by the charcoal surface. F. pH of the Solution The effect of the solution pH is extremely important when the adsorbing species is capable of ionizing in response to the prevailing pH (we speak of ionization rather than dissociation, because with basic substances a low pH causes a group such as -NH 2 to become protonated and exist in the form -NH3; thus, the molecule is ionized but it is not dissociated).
02 N HgCl2 solution be used (along with the methylene blue test) as a quantitative index of adsorption power. ) for HgCl2, I2, phenol, oxalic acid, potassium oxalate, strychnine sulfate, strychnine nitrate, morphine sulfate, and methylene blue. A great variation was found among the charcoals, with Supra-Norit being the best (probably because, like present-day Norit Supra charcoals, it had a large internal surface area for adsorption). Dingemanse and Laqueur (1926) further showed that, in vivo, in the pig stomach and intestine, after 55 min, 47% of an HgCl2 dose was adsorbed from the stomach and nearly all was adsorbed from the intestine.
Activated Charcoal in Medical Applications, Second Edition by David O. Cooney